Repaglinide (RPG) is poorly water soluble drug in BCS (Low solubility, High permeability). The objective of this study was to enhance the dissolution of RPG for oral drug delivery. RPG solid dispersions (F1-F12) were prepared by solvent evaporation method using PVP K30, PEG 4000, HPMC E5, HPMC E50 with a different drug: polymer ratios. The prepared SD were evaluated for drug content, practical yield, saturated solubility, in-vitro dissolution, X-ray diffraction, DSC, IR and SEM. The differential scanning calorimetry (DSC) thermograms and infra-red (IR) spectra revealed that there was no interaction of RPG with additives. RPG-SD gave higher solubility and faster dissolution rate when they compared to pure drug due to decrease of crystallinity of RPG which confirmed by XRD results. Repaglinide solid dispersions using PEG 4000 (1:2) as a polymer in solid dispersions showed promising results in enhancement of repaglinide properties.
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